Cardiac computed tomography (CT), particularly coronary CT angiography, may be used to non-invasively visualize coronary arteries and evaluate for significant atherosclerotic narrowing in selected patients. CT offers high spatial resolution and may be useful when pre-test probability is low to intermediate and when anatomical detail is needed. Considerations include exposure to ionizing radiation and contrast agents, which may be relevant for patients with renal impairment or contrast allergies. Access to advanced CT and experienced interpretation can influence test selection in practice.

Cardiac magnetic resonance imaging (MRI) provides detailed tissue characterization and can assess ventricular volumes, myocardial fibrosis, and congenital abnormalities without ionizing radiation. MRI may be particularly informative when echocardiography yields inconclusive results or when specific tissue information is required. Practical factors include scan duration, need for breath-holding, and contraindications such as certain implanted devices. Availability and scheduling may vary, and clinicians typically consider MRI when its additional information could change management.
Invasive coronary angiography remains the reference standard for direct visualization of coronary artery anatomy and is often performed when non-invasive testing suggests high likelihood of obstructive disease or when revascularization is being considered. The procedure typically requires vascular access, contrast administration, and specialized facilities. Procedural risks are generally low but include vascular complications and contrast-related effects; such considerations may influence pre-procedure evaluation and informed consent processes.
Nuclear myocardial perfusion imaging assesses regional blood flow to the myocardium and can be combined with stress protocols to detect reversible perfusion defects. This modality often provides functional information complementary to anatomical imaging and may be applied when prior tests are inconclusive. Limitations include exposure to radioisotopes and variable availability. Clinicians often balance diagnostic yield against resource considerations and patient-specific factors when choosing nuclear techniques.